Fitz and Skillet hold Rhoda hostage and question him about their strange town. Later, Fitz ambushes and questions Roostre who is hosting a get-together at his house with his friends Golden Joe, Peanut Cop, and the New Guy.
Fitz, Skillet, a Injured Eye & the New Guy travel to the Liquor Store with help from Liquor to fix the Eye's leg but soon he reveals a clone of the Eye from his shelve, meanwhile Shark cruises his car around town & Roostre makes peace with a giant Spider while trapped in it's web.
At the Liquor's Store, The Eye's surgery is a success, and his is repaired, later Liquor traps The Hand in a jar, meanwhile Spider drags a cocooned Roostre to a Desert Cave & plays the song "Booger Haze" by summoning Music Notes to destroy Roostre's Corn-Dog farm, Shark & the Rectangular Businessman pick up the annoying Green Sweatered Woman & drive for a while until the No Eye Square Guy rips her in half with his powers.
Fitz & Skillet escape & destroy the farm by using a Corn-Dog rocket-ship by exploding a cache of bombs, meanwhile Shark tries to get his broke-down car started while the Rectangular Businessman heads to a Harmonica Store.
Fitz & Skillet crash on a large skyscraper with the rocket-ship & later find a Green-Sweatered Woman split in half & turn her into a terminator-style robot, meanwhile At his store, Liquor performs a stand-up comedy routine for the Eyes, Roostre wants to destroy the town by summoning his Corn-Droid after discovering his farm destroyed.
Peanut Cop, now a fireman, picks up Liquor and goes drunk driving in his jet-powered firetruck, until Peanut eventually leaves, later Liquor reunites with Fitz at a large skyscraper, meanwhile Rectangular Businessman talks to the Clock about Shark & travel back to the monitor room to find out that the the Animal Chain was stolen, Roostre takes Spider to a hidden Corn-Droid.
The Hand crawls into the brain of the Producer Man & controls his body after being attacked by Pronto which he heads to a large skyscraper while Fitz, Skillet & Liquor use intravenous injections of meat to get to sleep.
Fitz had various dreams of him talking other people like Shark & Roostre but is woke up by Liquor, Meanwhile, Pronto goes to a graveyard, where he gives the Animal Chain to an eight-armed beast named Amalockh.
After being inside the skyscraper's elevator the Producer Man reaches Fitz, Skillet, and Liquor. Liquor x-rays his head to discover that the Hand is inside, translates the beeping sounds he is making & escape the skyscraper, meanwhile Shark kidnaps Mouse's friends & starts blowing up the city.
Fitz & Co. meet up with Roostre & Spider in the sewers system to get him his Hand back but Shark's minions wreck havoc on the city then Fitz, Skillet & Cyber Sweartered-Woman travel back to the surface to fight them & they reunite with Peanut Cop.
After traveling a ventilation system, Fitz & Co. kill finally Shark, save some of their friends & travel on a Shark shaped Jet, CJ Muff is then set free after the Corn-Droid breaks out of the Sewer system & Roostre has his hand back, meanwhile the Rectangular Businessman heads back to his bank, traps The Shadowy Figure in a jar & flies away.
Fitz awakens and finds himself without a memory, living in a new world called "Lotharganin." In this universe, he meets two top scientists named Aria and Professor Wilx. Golden Joe and Peanut Cop are contained within a jail cell, as Roostre is trapped in an unknown environment.
While Shark and the Rectangular Businessman are being reconstructed into an abomination of each other, Golden Joe and Peanut Cop continue to discover an escape from their jail cell. Along with this, Aria tries to jog Fitz's memory, with Wilx believing the latter is the core of the entire simulation experiment.
The Eye reunites with Mouse on Lotharganin, escaping Q109. Meanwhile, in the Outer Earth, Man-Woman is interrogated by a human cop due to her being in possession in the Box of Worlds, first created by Shyd Industries.
Roostre escapes from the World of Muck and finds himself in a desert with a well-armed Kid camping out. Peanut Cop and Golden Joe break out of prison on jet skis; Aria realizes that Professor Wilx is working for Shyd Industries.
At Shyd Industries, the Shadowy Figure meets with Sirus the Architect who designed the locking system that made the Box of Worlds escape-proof, Fitz receives an injection that recovers his memories of how he invented the Box and how to find the way out..
Mouse discovers the Box of Worlds has been stolen and is now unstable, jus as Golden Joe and Peanut Cop come to his rescue. Roostre meets Sirus, and devises a plan to take down Shyd Industries. Meanwhile, Wilx has found his way into Outer Earth.
Industry Man resurrects Wilx and questions Roostre on the whereabouts of Fitz, whom he fears will expose Shyd Industries' secrets if he escapes from the Box.The Green-Sweatered Woman alerts the Castellica, an AI construct in the form of an outer space RV castle piloted by Elize and Olof and sends it to save Fitz and Aria.
As the Castellica saves Mouse and team, Roostre escapes the clutches of Industry Man. Elize and Olof perform their song "Portal to the Doorway" then summon a thunderstorm, which teleports their allies across multiple worlds.